I heard a colleague talk today at the MidAtlantic Regional Meeting of the ACS about his work with fluoroquinones. These molecules (which despite their name contain no fluorine) fluoresce, that is they "glow" when exposed to light. The process can be short circuited by binding another molecule, a quencher, to fluoroquinone. The research discussed the quenching behavior of tryptophan. Tryptophan is an amino acid, one of the building blocks of proteins. Structurally, it's an indole; an aromatic six-membered ring fused to a five-membered ring containing a nitrogen forms the core.
Tryptophan is thought to induce sleep - and is often blamed for post-Thanksgiving meal naps. Melatonin, which also play a role in sleep regulation, is also an indole.
The indoles of chemistry get their name from the Latin for indigo, the dye from which the basic indole structure was first isolated. The indolence which some indoles induce has a different etymological root, dolorens - grief or pain.
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The Hayflick Limit: why humans can't live forever1 month ago in Genomics, Medicine, and Pseudoscience
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Course Corrections4 months ago in Angry by Choice
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The Site is Dead, Long Live the Site2 years ago in Catalogue of Organisms
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The Site is Dead, Long Live the Site2 years ago in Variety of Life
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Does mathematics carry human biases?3 years ago in PLEKTIX
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A New Placodont from the Late Triassic of China5 years ago in Chinleana
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Posted: July 22, 2018 at 03:03PM6 years ago in Field Notes
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Bryophyte Herbarium Survey6 years ago in Moss Plants and More
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Harnessing innate immunity to cure HIV8 years ago in Rule of 6ix
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WE MOVED!8 years ago in Games with Words
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post doc job opportunity on ribosome biochemistry!9 years ago in Protein Evolution and Other Musings
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Growing the kidney: re-blogged from Science Bitez9 years ago in The View from a Microbiologist
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Blogging Microbes- Communicating Microbiology to Netizens10 years ago in Memoirs of a Defective Brain
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The Lure of the Obscure? Guest Post by Frank Stahl12 years ago in Sex, Genes & Evolution
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Lab Rat Moving House13 years ago in Life of a Lab Rat
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Goodbye FoS, thanks for all the laughs13 years ago in Disease Prone
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Slideshow of NASA's Stardust-NExT Mission Comet Tempel 1 Flyby13 years ago in The Large Picture Blog
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in The Biology Files
The Who, What, When, Where and Why of Chemistry
Chemistry is not a world unto itself. It is woven firmly into the fabric of the rest of the world, and various fields, from literature to archeology, thread their way through the chemist's text.
Agonists and Allergies
My mast cells are leaking histamine and I am miserable. Histamine is a small molecule that binds to receptors in a wide variety of tissues including, alas, the respiratory system. It happens to increase vascular permeability - in other words, it's causing fluids to leak through my capillilary walls and into my nose. Sigh.
I'm fighting back by taking a histamine antagonist, diphenhydramine to be precise. Antagonists bind to a receptor and block its response, in this case inhibiting the H1 histamine receptors in the respiratory tract (H2 receptors cluster in the gastrointestinal tract - and so H2 antagonist, like Zantac, are used to treat heartburn). Agonists are molecules that bind to a receptor and cause a response. Why would you want to take something that binds to a histamine receptor and provoke a response? Turns out there are a couple of drugs that are histamine agonists, including one for Meniere's disease and another that may have theraputic potential for diabetes.
What does the term amine have to do with camel dung? Read about it here.
I'm fighting back by taking a histamine antagonist, diphenhydramine to be precise. Antagonists bind to a receptor and block its response, in this case inhibiting the H1 histamine receptors in the respiratory tract (H2 receptors cluster in the gastrointestinal tract - and so H2 antagonist, like Zantac, are used to treat heartburn). Agonists are molecules that bind to a receptor and cause a response. Why would you want to take something that binds to a histamine receptor and provoke a response? Turns out there are a couple of drugs that are histamine agonists, including one for Meniere's disease and another that may have theraputic potential for diabetes.
What does the term amine have to do with camel dung? Read about it here.
The Carbon Footprint of that Computer
Someone asked me over lunch yesterday if I was worried about global warming. "Worried enough to ride my bike to work through the hills of Bryn Mawr!" was my response. The conversation eventually turned to how much energy computers used - should you turn them off to save energy (and thereby reduce the amount of CO2 being dumped into the atmosphere)? Their IT support had said to leave the machines on, on the grounds that the amount of energy used to restart them outweighs any savings from turning them off at night. I thought this was not true, and some back of the envelope calculations suggest shutting down from the night (even putting the machine to sleep is not sufficient) is 10 times more energy efficient than leaving it on.
Powering up my machine takes 3 minutes at full tilt. At 120 watts, this uses up about 22 kJ of energy. If I left it in sleep mode all night (at 3.5 watts), it uses 228 kJ. I save about 200 kJ of energy, if I shut it off for the night, rather than just put it to sleep. It comes to about 44 pounds of carbon dioxide a year. It's a drop in the bucket compared to the per capita amount of carbon dioxide produced in the US (19.8 metric tons in 2003) - about 0.1%.
If you want to check your own carbon footprint, the EPA has a calculator.
Powering up my machine takes 3 minutes at full tilt. At 120 watts, this uses up about 22 kJ of energy. If I left it in sleep mode all night (at 3.5 watts), it uses 228 kJ. I save about 200 kJ of energy, if I shut it off for the night, rather than just put it to sleep. It comes to about 44 pounds of carbon dioxide a year. It's a drop in the bucket compared to the per capita amount of carbon dioxide produced in the US (19.8 metric tons in 2003) - about 0.1%.
If you want to check your own carbon footprint, the EPA has a calculator.
Acetylcholine and Cranky Suburbanites
I went to work today sporting a pair of molecular earrings: serotonin and norepinephrine to be precise. Two non-chemist colleagues spotted them and wondered about the significance of the molecules (and where to get them!). "Serotonin for serenity, norepinephrine for energy." "Ah, you're in balance then!" When I walked past ten minutes later they were browsing the molecular earring site and trying to figure out how to pronounce "acetyl" (as in acetylcholine). The site says that acetylcholine can promote creativity, learning, dreaming and memory. In passing, I noted that many pesticides are acetylcholinesterase inhibitors, they block the breakdown of acetycholine, which can have nasty effects on the body. Which led one colleague to wonder if that was why "suburban cul-de-sacs were such cranky places!"
Acetylcholine is a neurotransmitter, a small molecule that plays a role in transmitting signals along neurons. Originally found to stimulate the vagus nerve (responsible for controlling heart rate, among other things), it was christened vagustoff by Otto Loewi who eventually won the Nobel prize for its discovery. Curare blocks the receptor sites for acetylcholine, thus preventing muscle contraction (and causing respiratory arrest). You can have too much of a good thing, the venom of black widows causes synapses to be flooded with acetylcholine.
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vagus is from the Latin for wandering, which is what that nerve does...
Acetylcholine is a neurotransmitter, a small molecule that plays a role in transmitting signals along neurons. Originally found to stimulate the vagus nerve (responsible for controlling heart rate, among other things), it was christened vagustoff by Otto Loewi who eventually won the Nobel prize for its discovery. Curare blocks the receptor sites for acetylcholine, thus preventing muscle contraction (and causing respiratory arrest). You can have too much of a good thing, the venom of black widows causes synapses to be flooded with acetylcholine.
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vagus is from the Latin for wandering, which is what that nerve does...
Weird Words of Science 12: A need for speed
The nectar busily gathered by the bees outside my window has a high sucrose content. The bees add the enzyme invertase to the nectar to catalyze the inversion of the sucrose to glucose and fructose that are the major sugars in honey. Humans can speed up the same reaction by heating the syrup or by adding a touch of acid.
Both enzyme and catalysis are lofty words lifted by scientists in the 19th century to serve more prosaic ends.
Enzyme's first meaning in the bread used for the Eucharist in the Greek Orthodox tradition. It means "leavened". It's not such a stretch to borrow the word to describe stuff that encouraged cellular reactions to proceed, what had been called the ferment.
Catalysis was originally used to describe the collapse of a nation, its origins can be traced to the mid 17th century. It comes from the Greek "to loosen". In the 19th century, Berzelius suborned the term to describe the process by which chemical reactions are facilitated. Catalysts participate in a reaction, but are in the end are restored to their original form, like molecular Phoenixes. Why did Berzelius settle on this term? Did he hope to imply that the constraints which bound the reaction to a slow pace are loosened by a catalyst?
Both enzyme and catalysis are lofty words lifted by scientists in the 19th century to serve more prosaic ends.
Enzyme's first meaning in the bread used for the Eucharist in the Greek Orthodox tradition. It means "leavened". It's not such a stretch to borrow the word to describe stuff that encouraged cellular reactions to proceed, what had been called the ferment.
Catalysis was originally used to describe the collapse of a nation, its origins can be traced to the mid 17th century. It comes from the Greek "to loosen". In the 19th century, Berzelius suborned the term to describe the process by which chemical reactions are facilitated. Catalysts participate in a reaction, but are in the end are restored to their original form, like molecular Phoenixes. Why did Berzelius settle on this term? Did he hope to imply that the constraints which bound the reaction to a slow pace are loosened by a catalyst?
Turning Sugar Inside Out
This week's worksheet in general chemistry asks my students to analyze the chemical kinetics (the speed) of this reaction:
C12H22O11 (sucrose or table sugar) + H2O (water) -> C6H12O6 (glucose) + C6H12O6 (fructose).
It's called the inversion of sucrose, and the resulting mix of glucose and fructose is tagged invert sugar. The name suggests that table sugar has been turned inside out or perhaps upside down, but in fact it's simply been split into two simpler sugars. The inversion is not of the sugar itself, but of the way it bends polarized light. If you pass a beam of polarized light through a solution of regular table sugar, the light will "rotate" or bend to the left. The mixture of glucose and fructose "inverts" the rotation, and bends the beam to the right.
Invert sugar is less like to crystalize than regular sugar, making it ideal for sweetening candy or jams. The reaction in the absence of a catalyst is slow at room temperature, but can be completed . The simplest way to catalyze the reaction is with an acid, often citric acid or ascorbic acid (Vitamin C), and many jam recipes call for one or the other.
So why do these compounds "bend" polarized light? Like many biological molecules, they are chiral or handed. The right handed or D form bends the polarized light toward the right, the left handed form (denoted L) left.
Another name for the D form of glucose is dextrose, named for the direction in which it bends polarized light.
C12H22O11 (sucrose or table sugar) + H2O (water) -> C6H12O6 (glucose) + C6H12O6 (fructose).
It's called the inversion of sucrose, and the resulting mix of glucose and fructose is tagged invert sugar. The name suggests that table sugar has been turned inside out or perhaps upside down, but in fact it's simply been split into two simpler sugars. The inversion is not of the sugar itself, but of the way it bends polarized light. If you pass a beam of polarized light through a solution of regular table sugar, the light will "rotate" or bend to the left. The mixture of glucose and fructose "inverts" the rotation, and bends the beam to the right.
Invert sugar is less like to crystalize than regular sugar, making it ideal for sweetening candy or jams. The reaction in the absence of a catalyst is slow at room temperature, but can be completed . The simplest way to catalyze the reaction is with an acid, often citric acid or ascorbic acid (Vitamin C), and many jam recipes call for one or the other.
So why do these compounds "bend" polarized light? Like many biological molecules, they are chiral or handed. The right handed or D form bends the polarized light toward the right, the left handed form (denoted L) left.
Another name for the D form of glucose is dextrose, named for the direction in which it bends polarized light.
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