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Field of Science
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The Hayflick Limit: why humans can't live forever1 month ago in Genomics, Medicine, and Pseudoscience
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Course Corrections4 months ago in Angry by Choice
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The Site is Dead, Long Live the Site2 years ago in Catalogue of Organisms
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The Site is Dead, Long Live the Site2 years ago in Variety of Life
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Does mathematics carry human biases?3 years ago in PLEKTIX
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A New Placodont from the Late Triassic of China5 years ago in Chinleana
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Posted: July 22, 2018 at 03:03PM6 years ago in Field Notes
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Bryophyte Herbarium Survey6 years ago in Moss Plants and More
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Harnessing innate immunity to cure HIV8 years ago in Rule of 6ix
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WE MOVED!8 years ago in Games with Words
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post doc job opportunity on ribosome biochemistry!9 years ago in Protein Evolution and Other Musings
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Growing the kidney: re-blogged from Science Bitez9 years ago in The View from a Microbiologist
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Blogging Microbes- Communicating Microbiology to Netizens10 years ago in Memoirs of a Defective Brain
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The Lure of the Obscure? Guest Post by Frank Stahl12 years ago in Sex, Genes & Evolution
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Lab Rat Moving House13 years ago in Life of a Lab Rat
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Goodbye FoS, thanks for all the laughs13 years ago in Disease Prone
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Slideshow of NASA's Stardust-NExT Mission Comet Tempel 1 Flyby13 years ago in The Large Picture Blog
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in The Biology Files
The Who, What, When, Where and Why of Chemistry
Chemistry is not a world unto itself. It is woven firmly into the fabric of the rest of the world, and various fields, from literature to archeology, thread their way through the chemist's text.
Unnatural Amino Acids
Thirty years ago, it was assumed that all amino acid residues in naturally occurring polypeptides were in the L-form. We now know there are a few exceptions. For example, some polypeptide antibiotics found in fungi incorporate D-amino acids. It is thought that in most cases the peptide is synthesized with all L-amino acids, subsequently individual amino acids undergo enzymatically catalyzed epimerization. Only one such epimerase has been identified to date. The serine epimerase found in the venom of the funnel web spider, Agelenopsis aperta, selectively inverts the configuration of Ser-46 of the substrate omega-agatoxin-TK, leaving the other serine residue at position 28 untouched.
Oure termes so lerned and queynte
Whan we be ther where we shul exercise
Oure elvish craft, we seme wondrous wyse,
Yet wil I telle them, as they come to mynde,
Though I can not them set right in their kind;
As sal armoniak, verdegres, boras;
Geoffrey Chaucer, "The Canon's Yeoman's Tale" in The Canterbury Tales
Protein chemistry seems like a hot area, but the name given to the basic building blocks of proteins - amino acids - is in fact quite "queynte".
Chaucer's junior alchemist tries to impress the other pilgrims on the road with his knowledge of the terms of his "elvish craft", treating fellow-travelers to a free-associating litany of chemical names, herbs and equipment. Some terms remain familiar to modern chemists, who still ply their trade with vials and crucibles and can pull potassium carbonate off their shelves, others have left their traces in the learned terms of today. Traditionally, the earliest known production of what Chaucer calls "sal armoniak", or ammonium chloride, was from the burning of camel dung in the temple of Jupiter Ammon in what is now Libya – hence "sal ammoniac" or salt of Ammon. This term is the root for "amine" and eventually "amino acid".
See the whole Chaucerian litany in either Middle English or Modern English here. Want the full medieval experience? Images of the full text of two 15th century versions can be found here. You can read the Canon's Yeoman's Tale in (almost) it's original form thanks to the British Library.
Oure elvish craft, we seme wondrous wyse,
Yet wil I telle them, as they come to mynde,
Though I can not them set right in their kind;
As sal armoniak, verdegres, boras;
Geoffrey Chaucer, "The Canon's Yeoman's Tale" in The Canterbury Tales
Protein chemistry seems like a hot area, but the name given to the basic building blocks of proteins - amino acids - is in fact quite "queynte".
Chaucer's junior alchemist tries to impress the other pilgrims on the road with his knowledge of the terms of his "elvish craft", treating fellow-travelers to a free-associating litany of chemical names, herbs and equipment. Some terms remain familiar to modern chemists, who still ply their trade with vials and crucibles and can pull potassium carbonate off their shelves, others have left their traces in the learned terms of today. Traditionally, the earliest known production of what Chaucer calls "sal armoniak", or ammonium chloride, was from the burning of camel dung in the temple of Jupiter Ammon in what is now Libya – hence "sal ammoniac" or salt of Ammon. This term is the root for "amine" and eventually "amino acid".
See the whole Chaucerian litany in either Middle English or Modern English here. Want the full medieval experience? Images of the full text of two 15th century versions can be found here. You can read the Canon's Yeoman's Tale in (almost) it's original form thanks to the British Library.
Walking the tightrope: finding the timeless fundamentals in the context of modern physical chemistry
Today was a busy day, I gave another talk at the American Chemical Society meeting. This talk highlighted the ever present tensions in the physical chemistry curriculum between the expanding scope of modern physical chemistry and the timeless fundamentals. It was well summed up by one of my predecessors at Bryn Mawr - in 1913:
Can the curriculum be updated to include modern examples without compromising the basics? The NSF grant mentioned in my profile is for a new set of materials for teaching introductory physical chemistry that tries to bridge this gap. The materials draw from the recent primary research literature to illustrate key principles in multidisciplinary contexts. For example, the kinetics of first order reactions, illustrated in many current texts by a paper from 1921 reporting the rate of decomposition of gaseous N2O5, can be covered instead by following the racemization of amino acids used in the last decade to date archeological samples.
Resources mentioned in the talk, which I promised to post here are:
Talk less, they learn more
Do less, they learn more
Other resources:
“The contributions to knowledge in the domain of physical chemistry have increased with such rapidity within recent years that the prospective author of a general textbook finds himself confronted with the vexing problem of what to omit rather than what to include.” - Frederick H. Getman, 1913
Can the curriculum be updated to include modern examples without compromising the basics? The NSF grant mentioned in my profile is for a new set of materials for teaching introductory physical chemistry that tries to bridge this gap. The materials draw from the recent primary research literature to illustrate key principles in multidisciplinary contexts. For example, the kinetics of first order reactions, illustrated in many current texts by a paper from 1921 reporting the rate of decomposition of gaseous N2O5, can be covered instead by following the racemization of amino acids used in the last decade to date archeological samples.
Resources mentioned in the talk, which I promised to post here are:
Talk less, they learn more
- Using the pause procedure to enhance lecture recall. [Ruhl, K. L., Hughes, C. A., & Schloss, P. J. (1987, Winter). Teacher Education and Special Education, 10, 14-18]
- The importance of lecture in general-chemistry course performance [Birk, J.P., Foster, J. (1993) J Chem Ed 70 179]
- Departing from Lectures: An Evaluation of a Peer-Led Guided Inquiry Alternative [Lewis, S.E., Lewis, J.E. (2005) J Chem Ed 82 135]
- From Traditional to Radical [J. N. Spencer, Thought and Action, The NEA Higher Education Journal, XVII, No. 2 Winter 2001-2002]
- A Guided Inquiry Chemistry Course [J. J. Farrell, R. S. Moog, J. N. Spencer, J. Chem. Educ. 1999, 76, 570-574
Do less, they learn more
- Effects of lecture information density on medical student achievement [Russell. I.J., Hendricson, W.D., & Herbert, R.J. (November, 1984). Journal of Medical Education, 59, 881-889]
Other resources:
- POGIL:Physical Chemistry: A Guided Inquiry: Atoms, Molecules, and Spectroscopy, R. S. Moog, J. N. Spencer, J. J. Farrell; Houghton Mifflin: Boston, 2004.
- Physical Chemistry Online: Chem. Educator, 5 77-82 (2000) Deborah Sauder,* Marcy Towns, Betty Derrick, Alexander Grushow, Michael Kahlow, George Long, Danny Miles, George Shalhoub, Roland Stout, Michael Vaksman, William F. Pfeiffer, Gabriela Weaver, and Theresa Julia Zielinski
- Physical Chemistry in Context
- SymMath archive at Journal of Chemical Education
Replacing the Blackboard: Using Mathematica to Teach Modern Chemical Kinetics
In a talk I gave today at the American Chemical Society fall national meeting, I argued that moving the teaching of physical chemistry beyond what can be done on the blackboard or with pencil and paper can alter not only course pedagogy, but profoundly change course content. Analytical solutions to the differential rate equations often receive the bulk of the attention in an introductory physical chemistry course. Does this reflect the current practice in the field? Should this be the emphasis students take away? I think not. In response I developed a Mathematica based document for teaching chemical kinetics which builds on the traditional framework of analytical solutions, but develops numerical methods in concert, rather than as a special topic and shows how these numerical methods can be used to explore more exotic reactions, such as those that oscillate, or even exhibit chaotic behaviors.
Resources mentioned in the talk, which I promised to post here are:
Resources mentioned in the talk, which I promised to post here are:
- POGIL:Physical Chemistry: A Guided Inquiry: Atoms, Molecules, and Spectroscopy, R. S. Moog, J. N. Spencer, J. J. Farrell; Houghton Mifflin: Boston, 2004.
- Physical Chemistry Online: Chem. Educator, 5 77-82 (2000) Deborah Sauder,* Marcy Towns, Betty Derrick, Alexander Grushow, Michael Kahlow, George Long, Danny Miles, George Shalhoub, Roland Stout, Michael Vaksman, William F. Pfeiffer, Gabriela Weaver, and Theresa Julia Zielinski
- Physical Chemistry in Context
- SymMath archive at Journal of Chemical Education
Physical Chemistry, Metiu
Podcasting
Prompted by a talk last spring given by Jean-Claude Bradley of Drexel's chemistry department, I decided to try podcasting and webcasting my fall course. I submitted the podcast feed to Apple's iTunes, and wondered how many people outside of my course might be interested in listening. More than I might think, as Jean-Claude's post suggests.
So if you're intersted in following a quantum chemistry course, subscribe to the podcast through iTunes, or go to Chemistry221 where you can get both the podcast and a webcast.
So if you're intersted in following a quantum chemistry course, subscribe to the podcast through iTunes, or go to Chemistry221 where you can get both the podcast and a webcast.
Working up an appetite for momentum
This week we're "down the shore" as they say around here. We go to the same place each year and my kids have their traditional activities. For example, on the hottest day of the week we're there, we should rent a surrey (a pedicab with two seats and four sets of pedals -- this is not a light weight vehicle) and pedal it up and down the boardwalk for an hour, dodging pedestrians and other cyclists, until the parents (who provide most of the kinetic energy in this event) are soaked in sweat. The ride ends with a short ramp off the boardwalk, which this year Crash Kid was certain he could negotiate without parental assistance. Given his recent history with wheels, his parents were a bit less confident. The conversation quickly turned to momentum, and my spouse noted we had a lot of "m" in the buggy. My youngest thought this might stand for momentum. "Nope, that's 'p'!" his mom replied. Sensibly, he wanted to know why that letter!
Good question, and I'm not sure that I have a good answer for him yet. The lore seems to be that Newton used the term "impetus" in the Principia. Impetus is a Latin import, from petere to seek. Interestingly, the Indo-European root of petere is pter which gives us the Greek pteron (wing), and eventually helicopter. Petere is also the root of the English appetite -- which pedaling that surrey certainly worked up.
If anyone has other ideas about why "p" is used for momentum, I'd love to hear them!
Good question, and I'm not sure that I have a good answer for him yet. The lore seems to be that Newton used the term "impetus" in the Principia. Impetus is a Latin import, from petere to seek. Interestingly, the Indo-European root of petere is pter which gives us the Greek pteron (wing), and eventually helicopter. Petere is also the root of the English appetite -- which pedaling that surrey certainly worked up.
If anyone has other ideas about why "p" is used for momentum, I'd love to hear them!
Oil on the waters
Newsweek's Blogwatch highlights PZ Myers' Pharyngula blog and his altercation with George Gilder. While that post might have inflamed the blogosphere, the same issue considers a publication that recommends casting some calming "oil upon the waters".
A short text box highlights a recent paper (Barenblatt, Chorin, Prostokishin in PNAS Natl Acad Sci. 2005 Jul 27, pre-publication on web) by three mathematicians: "A note concerning the Lighthill "sandwich model" of tropical cyclones". The authors try to show that the maximum wind speeds that can be obtained above water depend on the turbulence of the flow. If you reduce the turbulence of the flow, the winds increase dramatically. They speculate that large water droplets thrown into the air reduce the turbulence and thus result in increased winds. The last paragraph of the article notes that in the distant past, sailors poured oil onto the waters to calm storms. Newsweek notes that a surfactant might work, and you might leave with the impression that oil is a surfactant.
Surfactants (from "surface active agents) reduce the surface tension of a liquid. When the surface tension is reduced, the size of droplets formed from the solution also decreases. So surfacants in theory could reduce the formation of large wind-blown droplets. Oil forms a physical barrier, since oil and water are immiscible, that prevents the water from being touched by the waves. Oil molecules are much heavier than water and less likely to form large stable droplets in the air. So both might work to calm a storm, but in chemically different ways.
My father spent much of his scientific career making surfactants. They see uses from the prosaic (read the back of your shampoo bottle, see something like sodium lauryl sulfate?) to the exotic (surfactants are used to treat premature babies' lungs).
A short text box highlights a recent paper (Barenblatt, Chorin, Prostokishin in PNAS Natl Acad Sci. 2005 Jul 27, pre-publication on web) by three mathematicians: "A note concerning the Lighthill "sandwich model" of tropical cyclones". The authors try to show that the maximum wind speeds that can be obtained above water depend on the turbulence of the flow. If you reduce the turbulence of the flow, the winds increase dramatically. They speculate that large water droplets thrown into the air reduce the turbulence and thus result in increased winds. The last paragraph of the article notes that in the distant past, sailors poured oil onto the waters to calm storms. Newsweek notes that a surfactant might work, and you might leave with the impression that oil is a surfactant.
Surfactants (from "surface active agents) reduce the surface tension of a liquid. When the surface tension is reduced, the size of droplets formed from the solution also decreases. So surfacants in theory could reduce the formation of large wind-blown droplets. Oil forms a physical barrier, since oil and water are immiscible, that prevents the water from being touched by the waves. Oil molecules are much heavier than water and less likely to form large stable droplets in the air. So both might work to calm a storm, but in chemically different ways.
My father spent much of his scientific career making surfactants. They see uses from the prosaic (read the back of your shampoo bottle, see something like sodium lauryl sulfate?) to the exotic (surfactants are used to treat premature babies' lungs).
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